Publications
2023
Women with Hearing Loss Show Increased Dementia Risk and Brain Atrophy. Fitzhugh, Megan C., and Judy Pa. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring 15, no. 4 (2023): e12499. Fitzhugh et al. 2023
Protective effects of sleep duration and physical activity on cognitive performance are influenced by B-amyloid and brain volume but not tau burden among cognitively unimpaired older adults. Aslanyan, V., Ortega N.E., Fenton, L.,Harrison T.M., Raman, R., Mack, W.J.,Pa J. Neurolmage: Clinical (2023),doi:10.1016/j.nicl.2023.103460.
Cerebrovascular reactivity in Alzheimer's disease signature regions is associated with mild cognitive impairment in adults with hypertension. Aslanyan V., Mack W.J., Ortega N.E., Nasrallah I.M., Pajewski N.M., Williamson J.D., Pa J. Alzheimer's Dement. 2023; 1-13. Aslanyan et al. 2023
Variability in objective sleep is associated with Alzheimer’s pathology and cognition. Fenton, L., Isenberg, A. L., Aslanyan, V., Albrecht, D., Contreras, J. A., Stradford, J., Monreal, T., & Pa, J. (2023). Brain communications, 5(2), fcad031. Fenton et al. 2023
Generalizability of cognitive results from clinical trial participants to an older adult population: Addressing external validity. Aslanyan, V., Pa, J., Hodis, H. N., St John, J., Kono, N., Henderson, V. W., Mack, W. J., & Alzheimer’s Disease Neuroimaging Initiative# (2023). Alzheimer’s & dementia (Amsterdam, Netherlands), 15(2), e12417. Aslanyan et al. 2023
AD and non-AD mediators of the pathway between the APOE genotype and cognition. Nichols E, Brickman AM, Casaletto KB, Dams-O'Connor K, George KM, Kumar RG, Palta P, Rabin JS, Satizabal CL, Schneider J, Pa J, La Joie R. Alzheimers Dement. 2023 Jun;19(6):2508-2519.
Protective effects of sleep duration and physical activity on cognitive performance are influenced by β-amyloid and brain volume but not tau burden among cognitively unimpaired older adults. Aslanyan V, Ortega N, Fenton L, Harrison TM, Raman R, Mack WJ, Pa J. Neuroimage Clin. 2023;39:103460.
The role of mitochondrial genome abundance in Alzheimer's disease. Harerimana NV, Paliwali D, Romero-Molina C, Bennett DA, Pa J, Goate A, Swerdlow RH, Andrews SJ. Alzheimers Dement. 2023 May;19(5):2069-2083.
Sex differences in associations between APOE ε2 and longitudinal cognitive decline. Wood ME, Xiong LY, Wong YY, Buckley RF, Swardfager W, Masellis M, Lim ASP, Nichols E, Joie R, Casaletto KB, Kumar RG, Dams-O'Connor K, Palta P, George KM, Satizabal CL, Barnes LL, Schneider JA, Binet AP, Villeneuve S, Pa J, Brickman AM, Black SE, Rabin JS; ADNI and Prevent-AD Research Groups. Alzheimers Dement. 2023 Oct;19(10):4651-4661.
2022
Sex-specific effects of microglial activation on Alzheimer’s disease proteinopathy in older adults. Casaletto KB, Nichols E, Aslanyan V, Simone SM, Rabin JS, LaJoie R, Brickman AM, Dams-O’Connor K, Palta P, Kumar RG, George KM. Brain. 2022 Jul 23.
Effects of Sex, APOE4, and Lifestyle Activities on Cognitive Reserve in Older Adults. Pa J, Aslanyan V, Casaletto KB, Rentería MA, Harrati A, Tom SE, Armstrong N, Rajan K, Avila-Rieger J, Gu Y, Schupf N. Neurology. 2022 Jul 20. Pa et al. 2022.
Longitudinal Changes in Resting-State Functional Connectivity and Gray Matter Volume Are Associated with Conversion to Hearing Impairment in Older Adults. Fitzhugh MC, Pa J. J Alzheimers Dis. 2022;86(2):905-918.
Subclinical carotid artery atherosclerosis and cognitive function in older adults. Lin F, Pa J, Karim R, Hodis HN, Han SD, Henderson VW, St John JA, Mack WJ. Alzheimers Res Ther. 2022 May 7;14(1):63.
Higher baseline levels of CSF inflammation increase risk of incident mild cognitive impairment and Alzheimer's disease dementia. Contreras JA, Aslanyan V, Albrecht DS, Mack WJ; Alzheimer's Disease Neuroimaging Initiative (ADNI); Pa J. Alzheimers Dement (Amst). 2022 Sep 19;14(1):e12346.
Cerebral amyloid angiopathy interacts with neuritic amyloid plaques to promote tau and cognitive decline. Rabin JS, Nichols E, La Joie R, Casaletto KB, Palta P, Dams-O'Connor K, Kumar RG, George KM, Satizabal CL, Schneider JA, Pa J, Brickman AM. Brain. 2022 Aug 27;145(8):2823-2833.
Sex-specific effects of microglial activation on Alzheimer's disease proteinopathy in older adults. Casaletto KB, Nichols E, Aslanyan V, Simone SM, Rabin JS, La Joie R, Brickman AM, Dams-O'Connor K, Palta P, Kumar RG, George KM, Satizabal CL, Schneider J, Pa J. Brain. 2022 Oct 21;145(10):3536-3545.
A Mitochondrial DNA Haplogroup Defines Patterns of Five-Year Cognitive Change. Watts A, Chalise P, Hu J, Hui D, Pa J, Andrews SJ, Michaelis EK, Swerdlow RH. J Alzheimers Dis. 2022;89(3):913-922.
2021
Simultaneous Exercise and Cognitive Training in Virtual Reality Phase 2 Pilot Study: Impact on Brain Health and Cognition in Older Adults. Sakhare A, Stradford J, Ravichandran R, et al. Brain Plasticity. 2021;7(2):111-130. Sakhare et al. 2021
Conducting a VR Clinical Trial in the Era of COVID-19. Stradford J, Sakhare A, Ravichandran R, Schroeder ET, Michener LA, Pa J. Frontiers in Virtual Reality. 2021 Apr 29;2:639478. Stradford et al. 2021
Early neuroinflammation is associated with lower amyloid and tau levels in cognitively normal older adults. Albrecht DS, Sagare A, Pachicano M, et al. Brain, Behavior and Immunity. 2021;94:299-307. Albrecht et al. 2021
2020
Associations between vascular function and tau PET are associated with global cognition and amyloid. Albrecht D, Isenberg AL, Stradford J, Monreal T, Sagare A, Pachicano M, Sweeney M, Toga A, Zlokovic B, Chui H, Joe E. Journal of Neuroscience.2020 Oct 12. PDF
Exploratory analysis of mtDNA haplogroups in two Alzheimer’s longitudinal cohorts. Swerdlow RH, Hui D, Chalise P, Sharma P, Wang X, Andrews SJ, Pa J, Mahnken JD, Morris J, Wilkins HM, Burns JM. Alzheimer’s & Dementia. 2020 Jun 16. PDF
APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline. Montagne A, Nation DA, Sagare AP, Barisano G, Sweeney MD, Chakhoyan A, Pachicano M, Joe E, Nelson AR, D’Orazio LM, Buennagel DP. Nature. 2020 May;581(7806):71-6.
Mitonuclear interactions influence Alzheimer’s disease risk.Andrews SJ, Fulton-Howard B, Patterson C, McFall GP, Gross A, Michaelis EK, Goate A, Swerdlow RH, Pa J, Alzheimer’s Disease Neuroimaging Initiative. Neurobiology of Aging. 2020 Mar 1;87:138-e7. PDF
Functional connectivity among brain regions affected in Alzheimer’s disease is associated with CSF TNF-α in APOE4 carriers. Contreras JA, Aslanyan V, Sweeney MD, Sanders LM, Sagare AP, Zlokovic BV, Toga AW, Han SD, Morris JC, Fagan A, Massoumzadeh P. Neurobiology of Aging. 2020 Feb 1;86:112-22. PDF
Late-life physical and cognitive activities independently contribute to brain and cognitive resilience. Casaletto KB, Rentería MA, Pa J, Tom SE, Harrati A, Armstrong NM, Rajan KB, Mungas D, Walters S, Kramer J, Zahodne LB. Journal of Alzheimer’s Disease. 2020. PDF
2019
Cycling and spatial navigation in an enriched, immersive 3D virtual park environment: A feasibility study in younger and older adults. Sakhare A, Yang V, Stradford J, Tsang I, Ravichandran R, Pa J. Frontiers in Aging Neuroscience 2019; 11: 218. PDF
Mitochondria and Alzheimer’s: Is PTCD1 the Smoking Gun? Pa J, Andrews SJ, Swerdlow RH. Trends in Neuroscience. 2019 Nov 1;42(11):759-62. PDF
APOE ɛ4 Gene Dose and Sex Effects on Alzheimer’s Disease MRI Biomarkers in Older Adults with Mild Cognitive Impairment. Hobel Z, Isenberg AL, Raghupathy D, Mack W, & Pa J. Journal of Alzheimer’s Disease. 2019 Jan 1;71(2):647-58. PDF
Assessing Test-Retest Reliability of Phase Contrast MRI for Measuring Cerebrospinal Fluid Flow Dynamics in Alzheimer’s Disease. Sakhare, A., Barisano, G., & Pa, J. Magnetic Resonance in Medicine. 2018: P3-183. PDF
Vascular dysfunction – The disregarded partner of Alzheimer’s disease. Sweeney, MD, Montagne, A, Sagare, AP, Nation, DA, Schneider, LS, Chui, HC, Harrington, MG, Pa, J, Law, M, Wang, JJ, et al. Alzheimer’s & Dementia. 2019 Jan;15(1):158-167. PDF
2018
Impairment of memory generalization in preclinical autosomal dominant Alzheimer’s disease mutation carriers. Petok JR, Myers CE, Pa J, Hobel Z, Wharton DM, Medina LD, Casado M, Coppola G, Gluck MA, & Ringman JM. Neurobiology of Aging. 2018 May 1;65:149-57. PDF
2017
Apolipoprotein E genotype and sex risk factors for Alzheimer disease: a meta-analysis. Neu SC, Pa J, Kukull W, Beekly D, Kuzma A, Gangadharan P, Wang LS, Romero K, Arneric SP, Redolfi A, & Orlandi D. JAMA Neurology. 2017 Oct 1;74(10):1178-89. PDF
A novel PSEN1 (S230N) mutation causing early-onset Alzheimer’s Disease associated with prosopagnosia, hoarding, and Parkinsonism. Ringman JM, Casado M, Van Berlo V, Pa J, Joseph-Mathurin N, Fagan AM, Benzinger T, Bateman RJ, & Morris JC. Neuroscience Letters. 2017 Sep 14;657:11-5. PDF
2016
Predictive big data analytics: A study of Parkinson’s disease using large, complex, heterogeneous, incongruent, multi-cource and incomplete observations. Dinov ID, Heavner B, Tang M, Glusman G, Chard K, Darcy M, Madduri R, Pa J, Spino C, Kesselman C, Foster I, Deutsch EW, Price ND, Van Horn JD, Ames J, Clark K, Hood L, Hampstead BM, Dauer W, & Toga AW. PLoS One. 2016 Aug 5;11(8). PDF
Brain imaging of neurovascular dysfunction in Alzheimer’s disease. Montagne A, Nation DA, Pa J, Sweeney MD, Toga AW, & Zlokovic BV. Acta Neuropathologica. 2016 May; 131(5):687-707. PDF
2015
Vascular plasticity and cognition during normal aging and dementia. Montagne A, Pa J, & Zlokovic B. JAMA Neurology. 2015 May; 72(5):495-6. PDF
2014
Effect of exercise and cognitive activity on self-reported sleep quality in community-dwelling older adults with cognitive complaints: a randomized controlled trial. Pa J, Goodson W, Bloch A, King AC, Yaffe K, & Barnes DE. Journal of American Geriatrics Society. 2014 Dec; 62(12):2319-26. PDF
Flavanol-rich food for thought. Pa J & Gazzaley A. Nature Neuroscience. 2014 Nov 21; 17(12):1624-5. PDF
The functional oculomotor network and saccadic cognitive control in healthy elders. Pa J, Dutt S, Mirsky JB, Heuer HW, Keselman P, Kong E, Trujillo A, Gazzaley A, Kramer JH, Seeley WW, Miller BL, & Boxer AL. Neuroimage. 2014 Jul 15; 95:61-8. PDF
Reliability measures of functional magnetic resonance imaging in a longitudinal evaluation of mild cognitive impairment. Zanto TP, Pa J, & Gazzaley A. Neuroimage. 2014 Jan 1; 84:443-52. PDF
Cholinergic enhancement of functional networks in older adults with mild cognitive impairment. Pa J, Berry AS, Compagnone M, Boccanfuso J, Greenhouse I, Rubens MT, Johnson JK, Gazzaley A. Annals of Neurology. 2013 Jun; 73(6):762-73. PDF
Longitudinal change in neuropsychological performance using latent growth models: a study of mild cognitive impairment. Johnson JK, Gross AL, Pa J, McLaren DG, Park LQ, Manly JJ. Brain Imaging & Behavior. 2012 Dec; 6(4):540-50. PDF
2012
Confirmatory factor analysis of the ADNI Neuropsychological Battery. Park LQ, Gross AL, McLaren DG, Pa J, Johnson JK, Mitchell M, Manly JJ. Brain Imaging & Behavior. 2012 Dec; 6(4):528-39. PDF
Cortical signatures of cognition and their relationship to Alzheimer’s disease. Gross AL, Manly JJ, Pa J, Johnson JK, Park LQ, Mitchell MB, Melrose RJ, Inouye SK, & McLaren DG. Brain Imaging & Behavior. 2012 Dec; 6(4):584-98. PDF
2010
Baseline predictors of clinical progression among patients with dysexecutive mild cognitive impairment. Johnson JK, Pa J, Boxer AL, Kramer JH, Freeman K, & Yaffe K. Dementia & Geriatric Cognitive Disorders. 2010; 30(4):344-51. PDF
Gray matter correlates of set-shifting among neurodegenerative disease, mild cognitive impairment, and healthy older adults. Pa J, Possin KL, Wilson SM, Quitania LC, Kramer JH, Boxer AL, Weiner MW, & Johnson JK. Journal of International Neuropsychological Society. 2010 Jul; 16(4):640-50. PDF
2009
Patterns of cerebral hypoperfusion in amnestic and dysexecutive MCI. Chao LL, Pa J, Duarte A, Schuff N, Weiner MW, Kramer JH, Miller BL, Freeman KM, & Johnson JK. Alzheimer Disease & Associated Disorders. 2009 Jul-Sep; 23(3):245-52. PDF
Rule violation errors are associated with right lateral prefrontal cortex atrophy in neurodegenerative disease. Possin KL, Brambati SM, Rosen HJ, Johnson JK, Pa J, Weiner MW, Miller BL, & Kramer JH. Journal of International Neuropsychological Society. 2009 May; 15(3):354-64. PDF
Clinical-neuroimaging characteristics of dysexecutive mild cognitive impairment. Pa J, Boxer A, Chao LL, Gazzaley A, Freeman K, Kramer J, Miller BL, Weiner MW, Neuhaus J, & Johnson JK. Annals of Neurology. 2009 Apr; 65(4):414-23. PDF
2008
Neural organization of linguistic short-term memory is sensory modality-dependent: evidence from signed and spoken language. Pa J, Wilson SM, Pickell H, Bellugi U, & Hickok G. Journal of Cognitive Neuroscience. 2008 Dec; 20(12):2198-210. PDF
Bilateral capacity for speech sound processing in auditory comprehension: evidence from Wada procedures. Hickok G, Okada K, Barr W, Pa J, Rogalsky C, Donnelly K, Barde L, & Grant A. Brain & Language. 2008 Dec; 107(3):179-84. PDF
A parietal-temporal sensory-motor integration area for the human vocal tract: evidence from an fMRI study of skilled musicians. Pa J & Hickok G. Neuropsychologia. 2008 Jan 15; 46(1):362-8. PDF